Genomics, Not Cookbook Medicine?

genomicsGenomics promises the next wave of medical innovation. It will remake clinical care. At least that’s what the genomics researchers say.

Today, medications get tested on thousands of people. Hopefully, safety and efficacy in thousands of study patients means medication will work on each individual patient.

Can we do better?

Genomics

Imagine if we could match someone’s exact genetic coding with a perfectly suited treatment? Genomics promises to do that, soon.

Personalized medicine, pharmacogenomics, presupposes individuality. People respond uniquely to medication. Currently, we aim for similar targets in every patient on a particular pill but are not surprised that individuals respond uniquely.

It explains why, all things being equal, a patient needs more medication than her sister for the same condition.

Not Cookbook Medicine

Genomics undermines a powerful movement. Evidence based medicine (EBM) has preached standardization, clinical practice guidelines and ‘quality’ for decades. Evidence based medicine swelled on the imprimatur of statistical analysis.

Devotees believe the path to excellence and efficiency lies on the narrow road of crisply defined process.

Top-Down Control

Academics, central planners and politicians love EBM. They wield EBM to proscribe medical deviance. Clinical judgement takes the hindmost.   Planners stand on giant studies and proclaim ideal treatment and best practices. Politicians lean on wayward physicians who allow too much patient choice in treatment, too much individuality.

Genomics delivers a new songbook. It sounds like old-fashioned pathophysiology that EBM discarded in the 1980s. Pathophysiology irritates statisticians and politicians. It encourages clinicians to think instead of memorizing clinical guidelines. Thinking is messy, hard to control.

Future

Genomics might become just another cookbook. It might dictate treatment based on computer analysis of patients’ genomes eliminating clinical judgment. Regardless, it will still ruin the one-size-fits-all approach clinicians get graded on now.

Hard core, individualized science might make a comeback. It will change everything. And it won’t be cheap.

photo credit: telegraph.co.uk.com

Healthcare’s Only Hope (is NOT Government)

healthcare's only hopeHealthcare loves new ideas that promise even a glimmer of improvement. Every new approach brings hope that maybe this will fix healthcare.

We believe that some one, or some thing, will put everything right.

Like Princess Leia, we believe our only hope exists but disagree on where to find it. (Video clip: “Help me Obi Wan Kanobi you’re my only hope.”)

We can organize fads or solutions by the level at which they promote their change.

Individuals

Some believe specific providers will deliver an ideal healthcare system. We just need nurse practitioner led clinics; more nurses, nursing assistants, more doctors…

All providers overlap in the services they provide. But healthcare’s far too diverse for us to believe one type of provider can be healthcare’s only hope.

Teams

‘Team care’ used to guarantee thoughtful nods from audiences. Specialized teams promised to solve everything from education to quality and efficiency. They help. But they don’t make individuals and organizations obsolete.

Organizations

Many pundits believe something like Kaiser Permanente offers healthcare’s only hope. Organizations and process solutions hold promise for operational efficiency. KP seems to deliver great patient service and holds collectivist values many find attractive in Canada. But they only serve select populations and have had to close down in some locations.

Social Institutions

  • Military?
  • Private business?
  • The free market?
  • Organized religion?
  • Unions?

 Government

Should we place our only hope in government?

If so, which level of government?

  • Municipalities don’t get enough help from the province.
  • Provinces continually ask for help from the feds, so clearly they can’t provide healthcare by themselves either.

Maybe a national plan would solve everything, like the British NHS we copied in the 1960s?

John Roberts served as a Liberal cabinet minister in the Trudeau and Turner governments.  In 2003, he wrote an essay in Searching for the New Liberalism: Essays in Renewal. He wrote that since the 1930s,

“…government departments multiplied and expanded, and a plethora, almost uncountable, of crown corporations was established.” 

Government was poor, however, at managing for a variety of reasons — the political processes of government militate against flexibility, decentralization and the delegation of responsibility; personnel management, an essential instrument of management, remains largely outside the hands of political direction; government does not have profit as a bottom line objective and therefore finds it difficult to apply as a means of bureaucratic control; the objectives of government are as mixed and as varied and as contradictory as the members of society.  These amorphous purposes, the lack of precision in purposes, make public management cumbersome rather than streamlined.”

Roberts, a believer in big government, says government cannot manage because:

  • Government resists flexibility, decentralization or delegation
  • Government struggles with personnel management
  • It has no bottom line for bureaucratic control (unlike profit in business)
  • There are too many objectives
  • Purposes are amorphous and imprecise

Healthcare’s Only Hope?

Here are some steps we might consider instead of searching for Obi Wan:

1. Stop looking for healthcare’s only hope. It does not exist. Complexity requires complex solutions.

2. Empower providers. Explore how ALL PROVIDERS can work to the full scope of their expertise. Not just nurses and pharmacists (as the latest only hope for healthcare). Doctors could supervise other providers in large clinics much like dentists.

3. Liberate, don’t regulate. Instead of saying “You can’t do that” we should say, “Show me how well you can do it.” Let individuals, teams, organizations and social institutions prove their worth in the results they deliver.

4. Challenge veto power and special interests. We are immobilized in a system where every stakeholder can insist why everyone else cannot do something or change the way they currently work. Everyone has veto power. Everyone can say “No” – Regulatory colleges, unions, associations, hospitals, and special interests.  No one allows anyone freedom to prove their worth.

5. Innovate, experiment and learn. Stop thinking healthcare is so concrete, so specialized. Most things do not have ONE obvious answer. Focusing on innovation, experimentation and outcomes could move us beyond our devotion to rigid ideas of evidence (logical positivism) without falling into postmodern relativity.

6. Challenge hegemony wherever it exists. Arbitrary governing authorities that regulate, legislate and manipulate healthcare according to their own vision of utopia guarantee stagnation.

7. Get government out of management. Only pride, power-lust or ignorance insists government manages best. Bureaucrats are not business leaders. Healthcare deserves the best leadership and management expertise available. Youthful poli-sci grads are great for many things, just don’t ask them to manage healthcare.

8. Empower Patients. They’re smart. For the most part, patients do not need, or want, to be passive, obedient recipients of healthcare largess. Patient empowerment and accountability offers a huge untapped opportunity to reform healthcare.

9. Diversify labour. Who, besides the unions, benefits from having 98% of the hospitals unionized in Ontario?

After we tackle these issues, we could examine hospital ownership, public health mandate, CCAC, LHINs, and much more, all within a national insurance plan like Medicare.

What to you think? Are we searching for healthcare’s only hope? Are we putting too much faith in government to save us? Are we hoping to find some other super-solution for all that ails healthcare?

 

Societal Opinion of Doctors

Societal Opinion of DoctorsAre doctors knights, knaves or pawns? Are they altruistic agents devoted to public service? Selfish conniving opportunists? Or hapless dupes, lacking agency or judgment? Are they conflicted villains?

Societal opinion dictates whether government policies are permissive, punitive or prescriptive (see JAMA article – 1st page only “Societal Perceptions of Physicians – Knights, Knaves, or Pawns?”). Opinion polls place doctors as valued members of society. But opinions change faster than fashion.

The British Economist, Julian Le Grand, discussed this in his book Motivation, Agency, and Public Policy: Of Knights and Knaves, Pawns and Queens.

The JAMA authors write:

“Le Grand’s work on post-World War II British social policy found that perceptions of human motivations gradually transformed, with the prevailing view of the typical British citizen morphing from knight to knave as the costs of maintaining an expensive welfare state increased.” (JAMA)

Knight – one on whom the dignity of knighthood is conferred because of personal merit or exemplary service to country

Knaverogue, scumbag, lowlife 

Pawn – a person manipulated or used to some end.  A puppet, tool or dupe

As money runs out, perceptions change.

Do doctors have a vision for healthcare? Do they know how to improve things for patients? Does anyone have a vision?

Healthcare uses up almost ½ of Ontario’s budget. Still people cry out for even more coverage (e.g., drugs). The system will fail without significant change.

Options:

  • More public monopoly (more accurately, monopsony )? More taxes? User fees?
  • Insurance driven (expensive) employee benefit plans? Like USA?
  • Out-sourced public offerings? More private management of the government monopoly?
  • European approaches? Everyone, except North Korea, allows citizens choice. Is it un-Canadian?
  • Public system with wait-time guarantee (i.e., government pays for care out of state if state can’t provide service)?

Doctors need to develop opinions about options. They need to speak with patients and local decision makers.

Le Grand’s comments aside, what doctors say and do drives societal opinion of them. As we run out of money (Ontario Will Eventually Have to Pay the Piper, Globe and Mail), what will physicians do?  What do doctors envision will improve the system?

If you work in healthcare, what’s your vision? If you’re a patient, what do you think needs to change?

Physicians have a choice. Come up with a positive vision to benefit patients or get bulldozed by policies based on societal perception of you as a pawn or knave. What will it be?